What is an Exosome?

1. Exosomes are cell-derived vesicles that are present in many and perhaps all biological fluids, including blood, urine, and cultured medium of cell cultures. The reported diameter of exosomes is between 30 and 100 nm, which is larger than LDL, but much smaller than for example, red blood cells.

We asked 10 prominent scientists to share their thoughts on science and in particular the field of exosomes research. The video-series tell the story and history of this exciting new area of research, and its impact on other research fields such as cancer and immunology. The video-series also discusses the potential future therapeutic and diagnostic applications that may come from exosome research.

Contributors:
– Xandra Breakefield, Ph.D……….. Professor, Massachusetts General Hospital
– Jan Lötvall, MD., Ph.D ………….. Professor, University of Gothenburg, President of ISEV
– Suresh Mohla, Ph.D……………… Chief (TBMB) and Division Associate Director, NIH
– Esther Nolte-‘t Hoen, Ph.D……… Senior Scientist, Utrecht University
– Michiel Pegtel, Ph.D…………….. Assistant Professor, VUmc, Amsterdam
– Graça Raposo-Benedetti, Ph.D.. Director of Research, CNRS, Institut Curie
– Phillip A. Sharp, Ph.D…………… Nobel Laureate, Professor, MIT
– Johan Skog, Ph.D……………….. CSO, Exosomes Diagnostics
– Dima Ter-Ovanesyan……………..Ph.D Student, Harvard University
– Clotilde Thery, Ph.D…………….. Director of Research, INSERM, Institut Curie, Secretary General of ISEV

Acknowledgements:
Members of the research groups of Michiel Pegtel (Cancer Center Amsterdam, VUmc), Graça Raposo-Benedetti (Structure and Membrane Compartments, CNRS, Institut Curie) and Clotilde Théry (Immunity and Cancer, INSERM, Institut Curie)

What is an Exosome?

The History and Promise of Exosomes

Exosomes in Cancer Research

Curiosity and a Passion for Science

Collaboration – the Key to Scientific Success

Exosomes – The Next Small Thing