Structure of Tumor-Suppressing Protein Identified

An international group of researchers led by Carnegie Mellon University physicists Mathias Lösche and Frank Heinrich have established the structure of an important tumor suppressing protein, PTEN. Their findings provide new insights into how the protein regulates cell growth and how mutations in the gene that encodes the protein can lead...

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Capturing cancer: 3-D model of solid tumors explains cancer evolution

This is a three-dimensional model of a tumor showing cell types in varying colors. Date:August 26, 2015 Source:Harvard University Summary:Researchers have developed the first model of solid tumors that reflects both their three-dimensional shape and genetic evolution. The new model explains why cancer cells have a surprising number of genetic mutations in common,...

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RESEARCHERS MIMIC VIRAL INFECTION IN COLON CANCER STEM CELLS

RESEARCHERS MIMIC VIRAL INFECTION IN COLON CANCER STEM CELLS, IDENTIFY DRUG-GABLE TARGET TO POTENTIALLY ROOT OUT DISEASE, END RELAPSE (TORONTO, Canada – Aug. 27, 2015) – ​Researchers targeting colorectal cancer stem cells – the root cause of disease, resistance to treatment and relapse – have discovered a mechanism to mimic a virus and potentially...

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Reprogramming cancer cells back to normal looks feasible, study shows

In many respects, cancer is like a complex software program of life that has got out of control; instead of the code for normal cells, a code for making abnormal cells is executed. Now, a new study in Nature Cell Biology suggests there may be a way to change the code so that cancer cells revert back to normal cells. Senior investigator Panos Anastasiadis,...

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Targeting glucose production in liver may lead to new diabetes therapies

DISABLING A CRITICAL CHECKPOINT FOR CONTROLLING GLUCOSE PRODUCTION IN THE LIVER REDUCES BLOOD SUGAR LEVELS IN MOUSE MODELS OF TYPE 2 DIABETES Date: September 3, 2015 Source: University of Iowa Health Care Summary: A biological checkpoint known as the Mitochondrial Pyruvate Carrier is critical for controlling glucose production in the liver and could...

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Disruption of a crucial cellular machine may kill the engine of deadly cancers

Date:September 2, 2015 Source:Baylor College of Medicine Summary:In a way, cancer resembles a runaway car with a gas pedal stuck to the floor, hurling out of control. Most new targeted cancer therapies seek to fix the gas pedal itself, and thus thwart the aggressive behavior of the tumor. But for many types of cancers, the pedal simply cannot be repaired, so new...

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